<!DOCTYPE html> <html lang="ko"> <head> <meta charset="UTF-8"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <title>Pipeline > New drugs > 퇴행성 뇌질환</title> <!-- css --> <link rel="stylesheet" href="/publish/common/css/reset.css"> <link rel="stylesheet" href="/publish/common/css/font.css"> <link rel="stylesheet" href="/publish/usr/layout/layout.css"> <link rel="stylesheet" href="/publish/usr/css/common.css"> <link rel="stylesheet" href="/publish/usr/css/style.css"> <link rel="stylesheet" href="/publish/usr/css/content.css"> <!-- //css --> <!-- script --> <script src="/publish/common/script/jquery-3.5.0.js"></script> <script src="/publish/usr/script/common.js"></script> <script src="/publish/usr/layout/layout.js"></script> <!-- //script --> </head> <body data-section="pipeline"> <div class="wrap"> <div data-include-path="/publish/usr/layout/_header.html"></div> <div id="container" class="container sub pipeline"> <div class="sub_visual"> <div class="inner"> <h2 class="sub_title" data-section="pipeline">PIPELINE</h2> <div class="sub_visual_nav"> <a href="/publish/usr/index.html"><i class="icon home"></i></a> <div class="snb_wrap"> <button type="button" class="snb_title">메뉴</button> <ul class="snb_select"> <li><a href="#">COMPANY</a></li> <li><a href="#">Platform Tech</a></li> <li><a href="#">Major Result</a></li> </ul> </div> <div class="snb_wrap"> <button type="button" class="snb_title">메뉴</button> <ul class="snb_select"> <li><a href="#">1depth</a></li> <li><a href="#">1depth</a></li> <li><a href="#">1depth</a></li> </ul> </div> </div> </div> </div> <div class="inner"> <div class="content_wrap pipeline skin"> <div class="contents"> <div class="content_title"> <h3>피부질환(건선/아토피)</h3> </div> <div class="figure_content column" data-aos="fade-down"> <div class="dl_wrap"> <dl> <dt> <b>경쟁사 치료제 개발 현황</b> </dt> <dd> <ul class="box_wrap white"> <li> <i></i> <p> <b>TNF-a 항체</b>에서 <b>Interleukin류</b> 항체 기반 주사제가 <b>시장 주도, 복용 편의성</b>과 <b>약가 부담</b>이 <b>한계점</b> </p> </li> <li> <i></i> <p> 더마반트사, 2022년 <b>AhR 작용제</b>인 <b>Tapinarof</b>(VTAMA®)에 대한 FDA <b>승인 획득</b> </p> </li> <li> <i></i> <p> <b>일라이 릴리, 넥시스 테라퓨틱스</b> 등 활발히 후속약물 개발 중, 이외 <b>글로벌 제약사 AhR기전 건선 치료제 개발</b> 중 </p> </li> </ul> </dd> </dl> <dl> <dt> <b>글로벌 시장 규모</b> </dt> <dd> <img src="/publish/usr/images/pipeline/skin_img01.png" alt=""> </dd> </dl> </div> <div class="dl_wrap fill accent"> <dl class="w100per"> <dt>오가시스 건선/아토피 치료제 개발 현황 및 계획</dt> <dd> <ol class="timeline_list"> <li> <div class="year">2024</div> <div class="line"></div> <div class="content"> <strong>선도물질 도출</strong> </div> </li> <li class="active"> <div class="year">2025</div> <div class="line"></div> <div class="content"> <strong>선도물질 최적화 및<b><br> 후보물질 도출</b></strong> <strong><b>특허출원</b></strong> </div> </li> <li> <div class="year">2026</div> <div class="line"></div> <div class="content"> <strong><b>경구형 및 적응증<br> 확대 국내 공동연구</b></strong> </div> </li> <li> <div class="year">2027</div> <div class="line"></div> <div class="content"> <strong><b>전임상(GLP Tox)</b></strong> <strong><b>국내 L/O</b> 추진</strong> </div> </li> <li> <div class="year">2028</div> <div class="line"></div> <div class="content"> <strong><b>P1 IND</b></strong> <strong><b>글로벌 L/O</b> 추진</strong> </div> </li> <li> <div class="year">2029~</div> <div class="line"></div> <div class="content"> <strong><b>임상 1상 완료</b></strong> </div> </li> </ol> </dd> </dl> </div> <div class="figure_content row tech_content"> <div class="box"> <img src="/publish/usr/images/pipeline/skin_img02.png" alt=""> <ul class="box_wrap border accent"> <li> <div class="title"><b class="number">1</b>스크리닝(AhR reporter assay)</div> <div class="box"> <img src="/publish/usr/images/pipeline/skin_img03.png" alt=""> </div> </li> <li> <div class="title"><b class="number">2</b>AhR nuclear translocation assay</div> <div class="box"> <img src="/publish/usr/images/pipeline/skin_img04.png" alt=""> </div> </li> <li> <div class="title"><b class="number">3</b>qRT-PCR(CYP1a1 expression)</div> </li> <li> <div class="title"><b class="number">4</b>염증성 사이토카인 level(IL-17a 등) 증감 평가 계획</div> </li> </ul> </div> <div class="box_wrap border purple"> <div class="title">Hit to Lead & Candidate evaluation</div> <div class="box"> <ul class="figure_desc square"> <li>Reporter gene 평가 : EC50  수 nM ~ pM</li> <li>Activated AhR Translocation : EC50 0.xnM</li> <li>Transcriptional Factor Evaluation : CYP1A1 등</li> <li>Barrier Gene Evaluation : FLG, NQO 등</li> <li>Various Skin & IBD Related Cell Evaluation</li> <li>Target Protein Binding : PAS-B Domain 등</li> <li>ADMET & Physical Property Evaluation</li> <li>Medi-Chem & Structures Optimization</li> <li>SAR & I.P Expansion</li> <li>In vivo Evaluation (Tox & Efficacy)</li> </ul> <img src="/publish/usr/images/pipeline/skin_img05.png" alt=""> </div> </div> </div> </div> </div> </div> </div> </div> <div data-include-path="/publish/usr/layout/_footer.html"></div> </div> </body> </html>