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<h3>피부질환(건선/아토피)</h3>
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<b>경쟁사 치료제 개발 현황</b>
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<b>TNF-a 항체</b>에서 <b>Interleukin류</b> 항체 기반
주사제가 <b>시장 주도, 복용
편의성</b>과 <b>약가 부담</b>이 <b>한계점</b>
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더마반트사, 2022년
<b>AhR 작용제</b>인 <b>Tapinarof</b>(VTAMA®)에 대한 FDA <b>승인 획득</b>
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<b>일라이 릴리, 넥시스 테라퓨틱스</b> 등 활발히 후속약물 개발 중,
이외 <b>글로벌 제약사 AhR기전 건선 치료제 개발</b> 중
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<div class="year">2024</div>
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<strong>선도물질 도출</strong>
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<div class="year">2025</div>
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<strong>선도물질 최적화 및<b><br> 후보물질 도출</b></strong>
<strong><b>특허출원</b></strong>
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<div class="year">2026</div>
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<strong><b>경구형 및 적응증<br> 확대 국내 공동연구</b></strong>
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<div class="year">2027</div>
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<strong><b>전임상(GLP Tox)</b></strong>
<strong><b>국내 L/O</b> 추진</strong>
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<div class="year">2028</div>
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<strong><b>P1 IND</b></strong>
<strong><b>글로벌 L/O</b> 추진</strong>
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<div class="year">2029~</div>
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<strong><b>임상 1상 완료</b></strong>
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<div class="title"><b class="number">1</b>스크리닝(AhR reporter assay)</div>
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<div class="title"><b class="number">2</b>AhR nuclear translocation assay</div>
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<div class="title"><b class="number">3</b>qRT-PCR(CYP1a1 expression)</div>
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<div class="title"><b class="number">4</b>염증성 사이토카인 level(IL-17a 등)
증감 평가 계획</div>
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<div class="title">Hit to Lead & Candidate evaluation</div>
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<li>Reporter gene 평가 : EC50 수 nM ~ pM</li>
<li>Activated AhR Translocation : EC50 0.xnM</li>
<li>Transcriptional Factor Evaluation : CYP1A1 등</li>
<li>Barrier Gene Evaluation : FLG, NQO 등</li>
<li>Various Skin & IBD Related Cell Evaluation</li>
<li>Target Protein Binding : PAS-B Domain 등</li>
<li>ADMET & Physical Property Evaluation</li>
<li>Medi-Chem & Structures Optimization</li>
<li>SAR & I.P Expansion</li>
<li>In vivo Evaluation (Tox & Efficacy)</li>
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