<!DOCTYPE html> <html lang="ko"> <head> <meta charset="UTF-8"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <title>리스트</title> <!-- css --> <link rel="stylesheet" href="../../../css/reset.css"> <link rel="stylesheet" href="../../../css/font.css"> <link rel="stylesheet" href="../layout/layout.css"> <link rel="stylesheet" href="../css/common.css"> <link rel="stylesheet" href="../css/style.css"> <link rel="stylesheet" href="../css/content.css"> <!-- //css --> <!-- script --> <script src="../../../js/jquery-3.5.0.js"></script> <script src="../script/common.js"></script> <script src="../layout/layout.js"></script> <!-- //script --> <!-- 캘린더 --> <script type="module" src="../../../js/plugin/datapicker/duet.esm.js"></script> <script nomodule src="../../../js/plugin/datapicker/duet.js"></script> <link rel="stylesheet" href="../../../js/plugin/datapicker/default.css"> </head> <body data-section="company"> <div class="wrap"> <div data-include-path="/publish/usr/layout/_header.html"></div> <div id="container" class="container sub company"> <div class="sub_visual"> <div class="inner"> <h2 class="sub_title" data-section="company">COMPANY</h2> <div class="sub_visual_nav"> <a href="../index.html"><i class="icon home"></i></a> <div class="snb_wrap"> <button type="button" class="snb_title">메뉴</button> <ul class="snb_select"> <li><a href="#">Company</a></li> <li><a href="#">Platform Tech</a></li> <li><a href="#">Major Result</a></li> </ul> </div> <div class="snb_wrap"> <button type="button" class="snb_title">메뉴</button> <ul class="snb_select"> <li><a href="#">1depth</a></li> <li><a href="#">1depth</a></li> <li><a href="#">1depth</a></li> </ul> </div> </div> </div> </div> <div class="inner"> <div class="content_wrap overview"> <div class="contents"> <div class="content_title"> <h3>설립배경</h3> </div> <div class="overview_contents_top"> <div class="txt"> <strong><span class="text_primary">ORGASIS</span> ORGASIS Corp.</strong> <p>organelles homeostasis control platform</p> </div> <ul class="card"> <li> <span class="number">01</span> <b class="title">현 약물의 한계</b> <span class="summary">단일 유전자, 단백질 타겟 약물 → 작용기전 및 유효성 등의 한계</span> </li> <li> <span class="number">02</span> <b class="title">능동적 약물 수요</b> <span class="summary">손상 또는 저하된 세포소기관의 선별적, 자발적 치료</span> </li> <li> <span class="number">03</span> <b class="title">과학적 증거 확대</b> <span class="summary">세포소기관과 여러 질병들과의 연관성에 관한 과학적, 임상적 자료의 급증</span> </li> <li> <span class="number">04</span> <b class="title">신규기술 - <br>신규 MoA 수요</b> <span class="summary">새로운 작용기전과 처방을 위한 신약 및 기능성 소재에 대한 시장 수요</span> </li> </ul> </div> <div class="overview_contents_bottom"> <div class="txt"> <strong>새로운 신약 후보물질의 <span class="text_primary">오아시스!</span></strong> <p>현 약물의 한계점을 극복하는 선택적, 자발적 항상성 작용기전 기반</p> </div> <div class="circles"> <div class="left"> <p class="circle line">Organelles</p> <p class="circle line">Homeostasis</p> </div> <div class="right"> <p class="circle fill">Organellostasis</p> </div> </div> </div> <div class="table_contents"> <div class="con_title" data-aos="fade-down"> <strong class="title">Best Next Generation Technologies inAging and Longevity (Selective Autophagy)</strong> </div> <div class="table_wrap" data-aos="fade-down"> <table> <colgroup> <col style="width:calc(100%/7);"> <col style="width:calc(100%/7);"> <col style="width:calc(100%/7);"> <col style="width:calc(100%/7);"> <col style="width:calc(100%/7);"> <col style="width:calc(100%/7);"> <col style="width:calc(100%/7);"> </colgroup> <thead> <tr> <th>Strata of organismal<br>organization</th> <th colspan="2">Hallmarks of aging</th> <th>작용기전<br>(유효성)</th> <th>신소재개발<br>(제형)측면</th> <th>문제점 또는<br>해결점</th> <th>미래<br>개선기술</th> </tr> </thead> <tbody> <tr> <td>Meta-organism</td> <td colspan="2"><img src="/publish/usr/images/company/background_img_01.png" alt=""><br>Dysbiosis</td> <td>X (Unclear)<br> - MoA X</td> <td>어려움<br> (미생물)</td> <td>효과검증<br> Q.C/Q.A 필요</td> <td>자동균총분석<br> 맞춤형균총</td> </tr> <tr> <td>Systemic circuitries</td> <td colspan="2"><img src="/publish/usr/images/company/background_img_02.png" alt=""><br>Altered cellular <br> communication</td> <td>X (Unclear)<br> - MoA X</td> <td>어려움<br> (Unclear)</td> <td>효과검증<br>  복합기전 규명 필요</td> <td>A.I signaling 분석<br> Meta분석, 맞춤형기술</td> </tr> <tr> <td>Organ systems</td> <td colspan="2"><img src="/publish/usr/images/company/background_img_03.png" alt=""><br>Deregulated <br> nutrient-sensing</td> <td>X (Unclear)<br> - MoA X</td> <td>어려움<br> (Unclear)</td> <td>효과검증<br> 프로세스개발, 기전검증</td> <td>Systemic분석 <br> 임상기술/맞춤형기술</td> </tr> <tr> <td>Organs</td> <td colspan="2"><img src="/publish/usr/images/company/background_img_04.png" alt=""><br>Deregulated <br> nutrient-sensing</td> <td>Unclear (o/x)<br> - MoA X</td> <td>어려움<br> (Unclear)</td> <td>부작용<br> 기전검증, 선택성 검증</td> <td>노화-만성염증 기전규명<br> 선택성과 맞춤형 기술</td> </tr> <tr> <td>Supracellular units</td> <td colspan="2"><img src="/publish/usr/images/company/background_img_05.png" alt=""><br>Stem cell exhaustion</td> <td>Unclear (o/x)<br> - MoA X</td> <td>어려움<br> (줄기세포)</td> <td>부작용<br> 발암이슈, 적용 방법</td> <td>줄기세포 안정화기술<br> 제형 및 QC기술 개발</td> </tr> <tr> <td>Cells</td> <td colspan="2"><img src="/publish/usr/images/company/background_img_06.png" alt=""><br>Senescence</td> <td>Unclear (o/x)<br> - MoA X</td> <td>어려움<br> (Unclear)</td> <td>프로세스, Q.C 문제<br> 복합기전 적용방법</td> <td>다중타겟검증<br> 제형/인공세포 기술</td> </tr> <tr class="emphasis_tr"> <td>Organelles</td> <td><img src="/publish/usr/images/company/background_img_07.png" alt=""><br>Disabled <br> autophagy</td> <td><img src="/publish/usr/images/company/background_img_08.png" alt=""><br>Mitochondrial <br> dysfunction</td> <td>O (높음)<br> - MoA O</td> <td>가능<br> (모두가능)</td> <td>선택성 개선</td> <td>선택적자가포식<br> (mitophagy)</td> </tr> <tr> <td rowspan="2">Molecules</td> <td><img src="/publish/usr/images/company/background_img_09.png" alt=""><br>Telomere <br> attrition</td> <td><img src="/publish/usr/images/company/background_img_10.png" alt=""><br>Genomic <br> instability</td> <td>O (미흡)<br> - MoA O</td> <td>가능<br> (모두가능)</td> <td>선택성/유효성/다양성</td> <td>선택성/지속성<br> 안전성개선 기술</td> </tr> <tr> <td><img src="/publish/usr/images/company/background_img_11.png" alt=""><br>Epigenetic <br> alterations</td> <td><img src="/publish/usr/images/company/background_img_12.png" alt=""><br>Loss of <br> proteostasis</td> <td>O (미흡)<br> - MoA O</td> <td>가능<br> (모두가능)</td> <td>선택성/유효성/다양성</td> <td>선택성/지속성<br> 복합제개발 등</td> </tr> </tbody> </table> </div> <ul class="box_wrap"> <li> <dl class="box skyblue"> <dt>유효성</dt> <dd> Molecule 수준의 복잡하고 비선택적 제어에서 <b>세포소기관(Organelles)</b>의 <span>총괄적 세포 노화 개선</span> </dd> </dl> </li> <li> <dl class="box blue"> <dt>선택성</dt> <dd> <b>노화</b>에 직접적인 <b>미토콘드리아의 기능</b> 복원, <b>선택적 자가포식의 <span>가역적인 세포 항상성 개선</span></b> </dd> </dl> </li> <li> <dl class="box purple"> <dt>안전성</dt> <dd> <b>손상된 미토콘드리아</b>를 <span>선택적</span><b>으로 제거</b> <b>타조직, 정상 소기관에 영향 없는 안전한 <span>원료 개발</span></b> </dd> </dl> </li> </ul> </div> </div> </div> </div> </div> <div data-include-path="/publish/usr/layout/_footer.html"></div> </div> </body> </html>